Determination of severity strata for three atopic dermatitis outcome questionnaires: definition of severity score ranges for the worst itch numerical scale and the atopic dermatitis symptom and impact scales (ADerm-SS and ADerm-IS). ) (2023)

Silverberg, J. I., Simpson, E.L., Calimlim, B.M., Litcher-Kelly, L., Li, X., Sun, X. und Leshem, Y.A. (2022).Determining severity strata for three questionnaires of patient-reported atopic dermatitis outcomes: Defining severity score ranges for the worst itch numerical scale and the atopic dermatitis symptom and impact scales (ADerm-SS and ADerm-IS).dermatology and therapy,12(12), 2817-2827.https://doi.org/10.1007/s13555-022-00836-5

Determining severity strata for three questionnaires of patient-reported atopic dermatitis outcomes: Defining severity score ranges for the worst itch numerical scale and the atopic dermatitis symptom and impact scales (ADerm-SS and ADerm-IS) ./ Silverberg, Jonatan I.; SimpsonEric L.; Calimlim, Brian M. et al.

Em:dermatology and therapy, Bd. 12, Nº. 12, 12.2022, p. 2817-2827.

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Silverberg, J. I., Simpson, E.L., Calimlim, BM, Litcher-Kelly, L, Li, X, Sun, X und Leshem, YA 2022, 'Determining severity strata for three questionnaires of patient-reported atopic dermatitis outcomes: Defining severity score ranges for the worst itch numerical scale and the atopic dermatitis symptom and impact scales (ADerm-SS and ADerm-IS)',dermatology and therapy, Bd. 12, No. 12, p. 2817-2https://doi.org/10.1007/s13555-022-00836-5

Silverberg J.I., Simpson EL, Calimlim BM, Litcher-Kelly L, Li X, Sun X et al.Determining severity strata for three questionnaires of patient-reported atopic dermatitis outcomes: Defining severity score ranges for the worst itch numerical scale and the atopic dermatitis symptom and impact scales (ADerm-SS and ADerm-IS).dermatology and therapy. December 2022; 12(12):2817-2827. doi: 10.1007/s13555-022-00836-5

SilverbergJonathan I.; SimpsonEric L.; Calimlim, Brian M. et al. /Determining severity strata for three questionnaires of patient-reported atopic dermatitis outcomes: Defining severity score ranges for the worst itch numerical scale and the atopic dermatitis symptom and impact scales (ADerm-SS and ADerm-IS). Em:dermatology and therapy. 2022; n.d. 12, Nº. 12. P. 2817-2827.

@article{0bcffbe85ba244afaf2d212cd100cab6,

title = "Determining Severity for Three Questionnaires of Patient-Reported Atopic Dermatitis Outcomes: Determining the Severity Score Ranges for the Worst Itch Numerical Scale and the Atopic Dermatitis Symptom and Impact Scales (ADerm-SS and ADerm-IS )",

abstract = “Introduction: Three patient-reported outcome (PRO) questionnaires were developed: Worst Numerical Itch Scale (WP-NRS), Atopic Dermatitis Symptom Scale (ADerm-SS), and Atopic Dermatitis Impact Scale (ADerm -IS) to assess the symptoms and effects of atopic dermatitis (AD). For these PROs, layers of gravity are needed to aid interpretation. METHODS: Using data from a global, randomized, phase 3, double-blind, placebo-controlled clinical trial (NCT03568318) of patients with moderately severe AD (age ≥ 12 years), percentile linkage analyzes were performed to define strata of severity with o Patient's global The impression of severity was performed as an anchor, which was performed separately for adults and adolescents and then harmonized between the two age groups.Results: The sample consisted of 769 adults and 113 adolescents, for the WP-NRS, 0 was associated with absent, 1-2 with minimal, 3 with easy, 4-7 with moderate and 8-10 with difficult. -SS skin pain, 0 was associated with absent, 1 with minimal, 2 with mild, 3 with 6 with moderate and 7 with 10 with severe. For the ADerm-SS 7-item total symptom score (TSS-7), 0-1 was associated with absence, 2-11 with minimal, 12-22 with mild, 23-47 with moderate, and 48-70 with severe. For ADerm-IS sleep, 0 was associated with no sleep, 1-3 with minimal sleep, 4-6 with light sleep, 7-20 with moderate sleep, and 21-30 with heavy sleep. For ADerm-IS daily activities, 0 was associated with absence, 1-2 with minimal, 3-7 with mild, 8-25 with moderate, and 26-40 with severe. For the ADerm-IS emotional state, 0 was associated with absent, 1-2 with minimal, 3-8 with mild, 9-22 with moderate, and 23-30 with severe. Conclusions: These severity layers provide interpretations of the WP-NRS, ADerm-SS, and ADerm-IS scores and translate these scores into simple, intuitive results that can inform clinical trials and clinical practice. Test registration number: NCT03568318.",

keywords="ADerm-IS, ADerm-SS, Atopic Dermatitis, Patient Reported Outcomes, Pruritus, Severities, Skin Pain, Sleep",

autor = "Silverberg, {Jonathan I} e Simpson, {Eric L.} e Calimlim, {Brian M.} e Leighann Litcher-Kelly e Xiaoran Li e Xiaowu Sun e Leshem, {Yael A.}",

nota="Funding information: Genotype data was provided by the Collaborative Genome Program to Foster a New Post-Genome Industry (3000-3031b). This study was funded by an internal grant from the National Institutes of Health, the National Control Agency of Disease Prevention and Control, Republic of Korea (2019-NG-053-02). Publisher copyright: {\textcopyright} 2022, The author(s).",

again="2022",

month = december,

doi = "10.1007/s13555-022-00836-5",

language = "English (United States)",

volume = "12",

pages="2817--2827",

Magazine = "Dermatology and Therapy",

issn = "2190-9172",

editor = "Springer Verlag",

number="12",

}

YOU - MARK

T1 - Determination of degrees of severity for three questionnaires of results reported by patients with atopic dermatitis

T2: Definition of severity score ranges for worse numerical rating scale of pruritus and atopic dermatitis symptoms and impact scales (ADerm-SS and ADerm-IS)

AU-Silverberg, Jonathan I.

DE-Simpson, Eric L.

AU - Calimlim, Brian M.

Australia - Litcher-Kelly, Leigh

Australia - Li, Xiaoran

AU - Sol, Xiaowu

AU-Leshem, Yael A.

N1 - Funding Information: Genotyping data were provided by the Collaborative Genome Program to Advance a New Post-Genome Industry (3000-3031b). This study was supported by an internal grant from the National Institute of Health, Agency for Disease Control and Prevention, Republic of Korea (2019-NG-053-02). Publisher Copyright: © 2022, The Author(s).

Fiscal year - 2022/12

A1 - 2022/12

N2 - Introduction: Three patient-reported outcome (PRO) questionnaires were developed: Worst Itch Numerical Scale (WP-NRS), Atopic Dermatitis Symptom Scale (ADerm-SS), and Atopic Dermatitis Impact Scale (ADerm-IS). ) to assess the symptoms and impact of atopic dermatitis (AD). Gravity layers are needed by these PROs to help with their roleplaying. Methods: Percentile linkage analyzes were performed to define strata of AD using data from a phase 3 global, randomized, double-blind, placebo-controlled clinical trial (NCT03568318) in patients with moderate to severe AD (age ≥ 12 years). Severity, which use the patient's total impression of severity as an anchor. Analyzes were performed separately for adults and adolescents and then harmonized between the two age groups. Results: The sample consisted of 769 adults and 113 adolescents. In the WP-NRS, 0 was associated with no, 1-2 with minimal, 3 with mild, 4-7 with moderate, and 8-10 with severe. For ADerm-SS skin pain, 0 was associated with no pain, 1 with minimal, 2 with mild, 3 with 6 with moderate, and 7 with 10 with severe. For the ADerm-SS 7-item total symptom score (TSS-7), 0-1 was associated with absence, 2-11 with minimal, 12-22 with mild, 23-47 with moderate, and 48-70 with severe. For ADerm-IS sleep, 0 was associated with no sleep, 1-3 with minimal sleep, 4-6 with light sleep, 7-20 with moderate sleep, and 21-30 with heavy sleep. For ADerm-IS daily activities, 0 was associated with absence, 1-2 with minimal, 3-7 with mild, 8-25 with moderate, and 26-40 with severe. For the ADerm-IS emotional state, 0 was associated with absent, 1-2 with minimal, 3-8 with mild, 9-22 with moderate, and 23-30 with severe. Conclusions: These severity layers provide interpretations of the WP-NRS, ADerm-SS, and ADerm-IS scores and translate these scores into simple, intuitive results that can inform clinical trials and clinical practice. Test registration number: NCT03568318.

AB - Introduction: Three patient-reported outcome (PRO) questionnaires were developed: Worst Itch Numerical Scale (WP-NRS), Atopic Dermatitis Symptom Scale (ADerm-SS), and Atopic Dermatitis Impact Scale (ADerm-IS). ). the symptoms and effects of atopic dermatitis (AD). Gravity layers are needed by these PROs to help with their roleplaying. Methods: Percentile linkage analyzes were performed to define strata of AD using data from a phase 3 global, randomized, double-blind, placebo-controlled clinical trial (NCT03568318) in patients with moderate to severe AD (age ≥ 12 years). Severity, which use the patient's total impression of severity as an anchor. Analyzes were performed separately for adults and adolescents and then harmonized between the two age groups. Results: The sample consisted of 769 adults and 113 adolescents. In the WP-NRS, 0 was associated with no, 1-2 with minimal, 3 with mild, 4-7 with moderate, and 8-10 with severe. For ADerm-SS skin pain, 0 was associated with no pain, 1 with minimal, 2 with mild, 3 with 6 with moderate, and 7 with 10 with severe. For the ADerm-SS 7-item total symptom score (TSS-7), 0-1 was associated with absence, 2-11 with minimal, 12-22 with mild, 23-47 with moderate, and 48-70 with severe. For ADerm-IS sleep, 0 was associated with no sleep, 1-3 with minimal sleep, 4-6 with light sleep, 7-20 with moderate sleep, and 21-30 with heavy sleep. For ADerm-IS daily activities, 0 was associated with absence, 1-2 with minimal, 3-7 with mild, 8-25 with moderate, and 26-40 with severe. For the ADerm-IS emotional state, 0 was associated with absent, 1-2 with minimal, 3-8 with mild, 9-22 with moderate, and 23-30 with severe. Conclusions: These severity layers provide interpretations of the WP-NRS, ADerm-SS, and ADerm-IS scores and translate these scores into simple, intuitive results that can inform clinical trials and clinical practice. Test registration number: NCT03568318.

KW - ADerm-ES

KW - ADermo-SS

KW - Atopic Dermatitis

KW - Results reported by the patient

KW - itch

KW - gravity layers

KW - dor na pele

KW - sleep

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URL: http://www.scopus.com/inward/citedby.url?scp=85141413050&partnerID=8YFLogxK

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TUN - 10.1007/s13555-022-00836-5

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JO - dermatology and therapy

JF - Dermatology and Therapy

Serial Number - 2190-9172

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